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Updated: Feb 15, 2026

Sample Preparation for Metabolic Profiling using MALDI Mass Spectrometry Imaging
Published on: December 22, 2020
MALDI imaging: beyond classic diagnosis
Laura Denise Manzanares-Meza1, Claudia Ivonne Gutiérrez-Román2, Oscar Medina-Contreras3
1Laboratorio de Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Mexico City, Mexico; Departmento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados, Mexico City, Mexico.
Abstract:
Mass spectrometry has been the focus of technology development and application for imaging for several decades. Imaging mass spectrometry using matrix-assisted laser desorption ionization is a new and effective tool for molecular studies of complex biological samples such as tissue sections. As histological features remain intact throughout the analysis of a section, distribution maps of multiple analytes can be correlated with histological and clinical features. Spatial molecular arrangements can be assessed without the need for target-specific reagents, allowing the discovery of diagnostic and prognostic markers of different cancer types and enabling the determination of effective therapies.
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