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Effect of a fish oil-based lipid emulsion on intestinal failure-associated liver disease in children

Tian Zhang1,2,3, Nan Wang2,3,4, Weihui Yan2,3,4

  • 1Department of Pediatric Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

European Journal of Clinical Nutrition
|February 1, 2018
PubMed

Insights

Fish oil therapy effectively treats liver disease in children with intestinal failure. This treatment reduced liver enzymes and inflammatory markers, improving patient outcomes.

Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Nutritional Science

Background:

  • Intestinal failure-associated liver disease (IFALD) is a serious complication in children requiring long-term parenteral nutrition (PN).
  • Current lipid emulsions may contribute to IFALD, necessitating alternative treatments.

Purpose of the Study:

  • To evaluate the efficacy of a fish oil-based lipid emulsion in managing IFALD in pediatric patients.
  • To assess the impact of fish oil on liver function tests, inflammation, and oxidative stress markers.

Main Methods:

  • A cohort of 32 children with IF on long-term PN were switched to fish oil emulsion when liver indicators exceeded normal levels.
  • Liver function tests, inflammatory markers (TNF-α, CRP, WBC), and oxidative stress markers were monitored.
  • Enteral nutrition intake was also assessed before and after fish oil therapy.

Main Results:

  • Fish oil therapy significantly reduced levels of key liver enzymes including TBA, ALT, AST, γ-GT, TB, and DB.
  • Inflammatory markers such as TNF-α, CRP, and WBC were significantly decreased.
  • Patients on fish oil showed increased enteral energy intake, indicating improved nutritional status.

Conclusions:

  • Fish oil-based lipid emulsion therapy is effective in alleviating IFALD in children.
  • This intervention improves liver function and reduces inflammation in pediatric patients with intestinal failure.
  • Fish oil represents a promising therapeutic option for managing IFALD.
Abstract

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