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Updated: Feb 15, 2026
08:43
Orthotopic Mouse Model of Colorectal Cancer
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Intrabilary obstruction by colorectal metastases
1Department of Surgery, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.
Journal of Surgical Case Reports
|February 1, 2018
Summary
Intrabiliary colorectal metastases, a rare condition, can cause obstructive jaundice. Differentiating these from new biliary neoplasms is crucial for appropriate patient therapy.
Area of Science:
- Gastroenterology
- Oncology
- Radiology
Background:
- Colorectal carcinoma can metastasize to the liver.
- Intrabiliary growth of metastases is exceptionally rare.
- Previous surgical history included right hemicolectomy and left hepatectomy.
Observation:
- An 84-year-old male presented with jaundice and weight loss.
- Magnetic resonance cholangiopancreatography (MRCP) revealed biliary tract obstruction.
- Histological examination confirmed adenocarcinoma consistent with colorectal origin.
Findings:
- The patient had obstructive jaundice due to intrabiliary colorectal metastases.
- Morphology and immunohistochemistry confirmed colorectal origin of the biliary lesion.
- Distinguishing from intraductal papillary neoplasm is critical.
Implications:
- Accurate diagnosis requires MRCP, ERCP, and immunohistochemistry.
- Timely differentiation ensures appropriate therapeutic strategies.
- Highlights a rare but significant metastatic pathway for colorectal cancer.
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