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Updated: Feb 15, 2026
09:29
Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
Published on: August 21, 2017
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[Neuromyelitis optica spectrum disorder and pregnancy]
N Borisow1, K Hellwig2, F Paul3,4
1NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Deutschland. nadja.borisow@charite.de.
Der Nervenarzt
|February 1, 2018
Summary
Pregnancy in women with Neuromyelitis Optica Spectrum Disorders (NMOSD) may increase postpartum disease activity and disability. Management requires careful consideration of therapy options and specialized supervision.
Area of Science:
- Neurology
- Immunology
- Reproductive Medicine
Background:
- Neuromyelitis Optica Spectrum Disorders (NMOSD) are autoimmune CNS inflammatory diseases predominantly affecting women.
- NMOSD can occur during women's reproductive years, raising concerns about family planning, pregnancy, and childbirth.
Purpose of the Study:
- To review the impact of NMOSD on fertility, pregnancy complications, and outcomes.
- To discuss pregnancy's effect on NMOSD disease course and available therapeutic strategies during gestation.
Main Methods:
- Literature search conducted using the PubMed database.
Main Results:
- Limited studies exist on fertility in NMOSD patients, though animal models suggest reduced fertility.
- Pregnancy in NMOSD is linked to increased postpartum disease activity and greater disability.
- Pregnancy complications like spontaneous abortion and preeclampsia may be more frequent in NMOSD patients.
Conclusions:
- Acute NMOSD relapses during pregnancy can be managed with methylprednisolone and/or plasma exchange/immunoadsorption.
- Decisions regarding continuing or stopping immunosuppressants like azathioprine or rituximab require careful risk-benefit assessment based on disease activity.
- Joint management by specialized centers is recommended for NMOSD patients, especially during pregnancy.
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