Related Experiment Video
Updated: Feb 15, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
[Visual recovery as the target for glaucoma]
V Chrysostomou1,2, R J Hatch1,2, T Colgan1,2
1Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, VIC 3002, East Melbourne, Australien.
Background:
Visual recovery is an established but poorly studied phenomenon in glaucoma.
Objective:
To provide insights into functional recovery of retinal ganglion cells (RGCs) with a view to providing information on the development of forms of treatment that improve RGC function after injury.
Method:
A model of recoverable RGC function in the mouse eye, induced by short-term elevation of intraocular pressure (IOP).
Results:
The RGCs manifest near complete functional recovery after a prolonged period of dysfunction following acute IOP elevation. Increasing age and a high fat diet were subsequently found to impair recovery, whereas exercise substantially improved recovery such that older mice recovered in a similar way to young mice.
Conclusion:
Injured RGCs have the capacity to restore function after periods of functional impairment. Therapies that specifically target injured RGCs and enhance their capacity to recover function may provide a new approach for treating glaucoma.
Related Concept Videos
Glaucoma: Overview
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
Muscle Recovery and Fatigue
Visual System
Once through the pupil, the light passes through the lens, a...
Targeted Cancer Therapies
There are several types of targeted therapies against...

