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Salivary proteomics in lichen planus: A relationship with pathogenesis?
M M Souza1, G P Florezi2, Mms Nico1
1Department of Dermatology, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
Oral Diseases
|February 1, 2018
Summary
Saliva proteomics identified 17 interacting proteins in oral lichen planus (OLP), potentially linked to Th17 cell activation and disease pathogenesis. These findings offer new insights into OLP development and potential biomarkers.
Area of Science:
- Oral medicine
- Immunology
- Proteomics
Background:
- Oral lichen planus (OLP) is a chronic inflammatory oral condition.
- Its pathogenesis involves T-cell mediated apoptosis and increased Th1/Th17 cells.
- The exact mechanisms driving OLP remain unclear.
Purpose of the Study:
- To identify protein markers in saliva associated with OLP.
- To elucidate the role of these proteins in OLP pathogenesis.
- To explore potential diagnostic or therapeutic targets.
Main Methods:
- Saliva samples from OLP patients and healthy controls were analyzed using mass spectrometry.
- Proteomics data underwent bioinformatics analysis (gene ontology, STRING networks).
- Multiplex analysis validated protein-cytokine correlations, focusing on Th17 pathways.
Main Results:
- 108 proteins were identified in OLP saliva.
- 17 proteins exhibited significant interactions, suggesting disease association.
- Protein expression correlated with cytokine release, particularly in Th17 responses.
Conclusions:
- Proteins like S100A8, S100A9, and haptoglobin were identified.
- These proteins may trigger cytokines and contribute to OLP pathology.
- Potential roles in antioxidant activity and disease mechanisms were suggested.
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