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Viral safety of coagulation factor concentrates: memoirs from an insider

P M Mannucci1

  • 1Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Ca' Granda Maggiore Policlinico Hospital Foundation, Milan, Italy.

Journal of Thrombosis and Haemostasis : JTH
|February 1, 2018
PubMed

Insights

Global efforts in 1985-1990 improved viral safety for coagulation factor concentrates. Lessons from hepatitis control informed successful HIV transmission strategies in patients with hemophilia.

Area of Science:

  • Hematology
  • Virology
  • Public Health

Background:

  • Coagulation factor concentrates are crucial for patients with hemophilia (PWHs).
  • The period 1985-1990 saw significant challenges with bloodborne viral infections, including hepatitis and HIV, in PWHs.
  • Confusing information complicated the management of viral safety in hemophilia treatment.

Observation:

  • Early measures to control hepatitis transmission in PWHs had limited success.
  • Understanding hepatitis control failures provided critical insights.
  • The progression of knowledge on viral transmission was essential for developing effective strategies.

Findings:

  • Global actions were taken to enhance viral safety of coagulation factor concentrates.
  • The approach to HIV transmission control was ultimately successful.
  • Knowledge gained from hepatitis virus control informed HIV strategies.

Implications:

  • Improved viral safety protocols for blood products are vital.
  • Historical analysis of viral outbreaks informs current public health responses.
  • Successful strategies for managing bloodborne viruses in immunocompromised populations can be developed through rigorous scientific understanding and adaptive measures.

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