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A Protocol for Explant Cultures of IDH1-mutant Diffuse Low-grade Gliomas
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Diffuse low-grade glioma mimicking ischaemic infarct: a case report
Gaigai Li1, Yanyan Li1, Yang Hu1
1a Department of Neurology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
The International Journal of Neuroscience
|February 1, 2018
Summary
A rare case of diffuse low-grade glioma (LGG) presented with stroke-like symptoms, highlighting diagnostic challenges. Early misdiagnosis as ischemic stroke was avoided with advanced imaging like Magnetic Resonance Spectroscopy (MRS) and biopsy.
Area of Science:
- Neuro-oncology
- Neurology
- Diagnostic Imaging
Background:
- Diffuse Low-Grade Gliomas (LGGs), WHO grade II, often present with subtle neurological symptoms.
- Early diagnosis of LGGs is crucial but can be challenging due to non-specific symptoms.
Observation:
- A 49-year-old female initially presented with symptoms and imaging mimicking an ischemic infarct.
- Standard stroke treatments led to fluctuating and then worsening symptoms.
- Lesion location did not align with vascular territories; CT angiography and Doppler were inconclusive.
Findings:
- Magnetic Resonance Spectroscopy (MRS) and stereotactic biopsy confirmed a WHO grade II, isocitrate dehydrogenase (IDH)-wild-type diffuse astrocytoma.
- This represents the first reported case of an LGG with a stroke-like onset.
- The case underscores the potential for misdiagnosing LGGs as stroke based solely on initial CT and MRI.
Implications:
- Highlights the importance of considering LGG in stroke mimics, especially when imaging is atypical.
- Emphasizes the role of advanced diagnostics like MRS and biopsy in accurate LGG diagnosis.
- Avoiding misdiagnosis prevents delayed or inappropriate treatment for LGG patients.
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