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The relationship between HDAC6, CXCR3, and SIRT1 genes expression levels with progression of primary open-angle

Mateusz Siwak1, Marcin Maślankiewicz1, Alicja Nowak-Zduńczyk1

  • 1a Department of Clinical Chemistry and Biochemistry , Medical University of Lodz , Lodz , Poland.

Ophthalmic Genetics
|February 1, 2018
PubMed
Abstract

Insights

Gene expression of HDAC6, CXCR3, and SIRT1 is linked to the progression of primary open-angle glaucoma (POAG). This study investigated these genes

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Genetics

Background:

  • Primary open-angle glaucoma (POAG) is a neurodegenerative disease with incompletely understood etiology.
  • Biochemical molecules are implicated in retinal ganglion cell damage in POAG.
  • Investigating specific gene expression may elucidate POAG pathogenesis.

Purpose of the Study:

  • To evaluate the relationship between HDAC6, CXCR3, and SIRT1 gene expression levels and POAG occurrence risk.
  • To assess the association of these gene expression levels with POAG progression.
  • To explore potential biomarkers for POAG development and advancement.

Main Methods:

  • Study included 34 POAG patients and 32 healthy controls.
  • RNA was isolated from peripheral blood lymphocytes.
  • Messenger RNA (mRNA) expression levels were quantified using real-time polymerase chain reaction (PCR).

Main Results:

  • Significant association found between HDAC6 and SIRT1 expression and POAG progression based on rim area (RA).
  • CXCR3 expression levels correlated with POAG progression concerning RA and cup-to-disc ratio (c/d).
  • Statistical significance (p < 0.05) was observed for all associated findings.

Conclusions:

  • HDAC6, CXCR3, and SIRT1 gene expression may play a role in POAG progression.
  • These genes represent potential targets for understanding and managing POAG.
  • Further research is warranted to confirm the role of these genes in POAG pathogenesis.
Keywords:
Genes expressionglaucomaneurodegenerationprogression

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