Spontaneous cerebrospinal fluid rhinorrhea: A case report and analysis
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Updated: Feb 15, 2026

Sample Preparation for Endopeptidomic Analysis in Human Cerebrospinal Fluid
Published on: December 4, 2017
Guang Yong Chen1, Long Ma, Mei Ling Xu
1First Department of Neurosurgery Department of Rheumatology Department of Clinical Laboratory Diagnostics, Sino-Japanese Friendship Hospital of Jilin University, Changchun, Jilin Province, China.
Introduction:
Spontaneous cerebrospinal fluid leakage is usually caused by developmental abnormalities and is rare, accounting for approximately 5% of the cases of cerebrospinal fluid (CSF) leakage. To the best of our knowledge, clival dysplasia-caused CSF rhinorrhea has never been reported in the neurosurgical field.
Conclusion:
Spontaneous cerebrospinal fluid rhinorrhea is often treated by surgery, and a transsphenoidal approach repair is the main surgical method used, offering the advantages of less trauma, fewer complications, rapid postoperative recovery, and low recurrence rate.
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