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Abnormal glucose regulation in Chinese patients with coronary artery disease: A cross-sectional study

Lei Meng1, Han-Yin Wang, Wen-Hui Ding

  • 1Department of Cardiology, Peking University First Hospital, Beijing, P.R. China.

Medicine
|February 1, 2018
PubMed

Insights

Abnormal glucose regulation (AGR) is highly prevalent in Chinese patients with coronary artery disease (CAD) and independently linked to acute coronary events. Early intervention for prediabetes in these patients may be beneficial.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Coronary artery disease (CAD) is a leading cause of mortality worldwide.
  • Glucose metabolism disorders are increasingly recognized in patients with cardiovascular disease.
  • Understanding the prevalence and impact of abnormal glucose regulation (AGR) in Chinese CAD patients is crucial.

Purpose of the Study:

  • To determine the prevalence of AGR in Chinese patients with established CAD.
  • To investigate the association between AGR and acute coronary events in this population.

Main Methods:

  • A cohort of 3441 hospitalized patients with established CAD was recruited across China.
  • Oral glucose tolerance tests (OGTT) were performed on 2112 patients without known diabetes.
  • Acute coronary events were systematically recorded, and multivariate analysis was used to assess associations.

Main Results:

  • AGR was detected in 85% of the total study cohort.
  • Among patients undergoing OGTT, 89% had AGR, including impaired glucose tolerance (59.9%) and diabetes (17.2%).
  • AGR was independently associated with an increased risk of acute coronary events after adjusting for traditional risk factors.

Conclusions:

  • The prevalence of AGR is high and increasing among Chinese patients with CAD.
  • AGR is an independent risk factor for acute coronary events in this population.
  • Further prospective studies are needed to evaluate the benefits of prediabetes interventions in adult CAD patients.

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