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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Improvement of chronic hepatitis B by iron chelation therapy in a patient with iron overload: A case report
Dong-Mei Zou1, Dong-Dong Rong, Hong Zhao
1Department of Hematology Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, P. R. China.
Rationale:
This report describes seroconversion of hepatitis B surface antigen (HBsAg) in a patient with marked iron overload caused by chronic hepatitis B (CHB) after receiving iron chelation therapy and discusses the role of iron chelation therapy in CHB.
Patient Concerns:
Increased serum ferritin level for 2 months.
Diagnosis:
Secondary iron overload and CHB.
Intervention:
To relieve iron load of the body, the patient underwent regular phlebotomy therapy and deferoxamine (DFO) therapy. During the therapy, serum ferritin and hepatitis B virus (HBV) were monitored and the iron concentration of the liver and heart were followed by T2* of magnetic resonance imaging (MRI) scan.
Outcomes:
Serum ferritin gradually decreased. Approximately 1 year after the therapy, HBsAg turned persistently negative.
Lessons:
Iron chelation therapy may attenuate HBV infection.
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