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Updated: Feb 15, 2026

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Polymeric Micelle of A₃B-Type Lactosome as a Vehicle for Targeting Meningeal Dissemination
Kensuke Kurihara1, Motoki Ueda2, Isao Hara3
1Clinical Division of Diagnostic Radiology, Kyoto University Hospital 54 Shogoin Kawara-cho, Sakyo-ku, Kyoto 606-8507, Japan. kurihara@kuhp.kyoto-u.ac.jp.
Abstract:
Polymeric micelle of the A₃B-type lactosome comprising (poly(sarcosine))₃-b-poly(l-lactic acid) was labeled with 111In. The 111In-labeled A₃B-type lactosome was administered to the model mice bearing meningeal dissemination and bone metastasis at mandible. With single-photon emission computed tomography (SPECT) imaging, the meningeal dissemination was identified successfully by 111In-labeled A₃B-type lactosome, which was superior to 201TlCl in regard of the imaging contrast. The 111In-labeled A₃B-type lactosome was also potential in imaging selectively of bone metastasis at mandible, whilst a nonspecific imaging of the whole bone was obtained by the SPECT imaging using 99mTc-HMDP. The polymeric micelle of the A₃B-type lactosome was therefore found to be effective as a vehicle of 111In to be targeted to meningeal dissemination and bone metastasis.
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