Related Experiment Video

Updated: Feb 15, 2026

Reconstruction of Single-Cell Innate Fluorescence Signatures by Confocal Microscopy

Reconstruction of Single-Cell Innate Fluorescence Signatures by Confocal Microscopy

Published on: May 27, 2020

TOXsIgN: a cross-species repository for toxicogenomic signatures

Thomas A Darde^1,2, Pierre Gaudriault¹, Rémi Beranger¹

¹Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S1085, F-35000 Rennes, France.

Bioinformatics (Oxford, England)

|February 1, 2018

Abstract

Motivation:

At the same time that toxicologists express increasing concern about reproducibility in this field, the development of dedicated databases has already smoothed the path toward improving the storage and exchange of raw toxicogenomic data. Nevertheless, none provides access to analyzed and interpreted data as originally reported in scientific publications. Given the increasing demand for access to this information, we developed TOXsIgN, a repository for TOXicogenomic sIgNatures.

Results:

The TOXsIgN repository provides a flexible environment that facilitates online submission, storage and retrieval of toxicogenomic signatures by the scientific community. It currently hosts 754 projects that describe more than 450 distinct chemicals and their 8491 associated signatures. It also provides users with a working environment containing a powerful search engine as well as bioinformatics/biostatistics modules that enable signature comparisons or enrichment analyses.

Availability And Implementation:

The TOXsIgN repository is freely accessible at http://toxsign.genouest.org. Website implemented in Python, JavaScript and MongoDB, with all major browsers supported.

Supplementary Information:

Supplementary data are available at Bioinformatics online.

More Related Videos

Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation

Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation

Published on: February 7, 2012

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

Published on: October 26, 2017

Related Concept Videos

What is a Species?

What is a Species?

Crossing Over

Crossing Over

Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...

Crossing Over

Crossing Over

Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I,...

Keystone Species

Keystone Species

Measures of species biodiversity, such as richness (i.e., the number of species present) and evenness (i.e., their relative abundance), describe an ecological community’s structure. Many factors affect community structure, including abiotic factors (e.g., sunlight and nutrients), disturbances (e.g., fire or flood), species interactions (e.g., predation or competition), and chance events (e.g., foreign species invasion). Certain species—such as keystone species—also play a...

Formation of Species

Formation of Species

Speciation describes the formation of one or more new species from one or sometimes multiple original species. The resulting species are discrete from the parent species, and barriers to reproduction will typically exist. There are two primary mechanisms, speciation with and without geographic isolation—allopatric and sympatric speciation, respectively.

Monohybrid Crosses

Monohybrid Crosses

Articles linked to this work by shared authors, journal, and citation graph.

Variability of urinary concentrations of glycol ether metabolites in pregnant women according to various sampling methods.

Journal of exposure science & environmental epidemiology·2026

Sequence-robust MRI asymmetry measures for the detection of anoperineal lesions in Crohn's disease on axial pelvic MRI scans.

PloS one·2026

Heterozygous loss-of-function alleles associate the conserved 3'-5' exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5-fluorouracil.

Molecular oncology·2026

Prenatal exposure to persistent organic pollutants and body mass index trajectories from birth to age 13.

Environmental research·2026

Levers to decrease exposure to harmful chemicals: the case of Personal Care Products and cosmetics.

Environment international·2026

Heat during Pregnancy and Reduced Fetal Growth: Critical Windows of Exposure and the Intertwined Role of Air Pollution, Vegetation, and Social Stressors.

Environmental science & technology·2026

See all related articles