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Updated: Feb 15, 2026

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments
Published on: May 26, 2019
CHARACTERIZATION OF 27 MEV PROTON BEAM GENERATED BY TOP-IMPLART LINEAR ACCELERATOR
C De Angelis1, A Ampollini2, E Basile3
1Istituto Superiore di Sanità (ISS), Viale Regina Elena 299, Rome, Italy.
The TOP-IMPLART project is developing a novel proton linear accelerator for cancer therapy. Initial tests show excellent beam reproducibility and homogeneity, crucial for precise radiation treatments.
Area of Science:
- Medical Physics
- Particle Accelerator Technology
- Radiation Oncology
Background:
- Development of advanced particle accelerators is crucial for precise cancer treatment.
- Proton therapy offers advantages over traditional radiation due to its Bragg peak phenomenon.
- The TOP-IMPLART project aims to create a cutting-edge proton therapy system.
Purpose of the Study:
- To characterize the beam properties of a new proton linear accelerator for tumor therapy.
- To assess beam homogeneity and reproducibility at energies relevant for radiobiological studies.
- To validate the performance of the actively scanned beam system.
Main Methods:
- Utilized a 2D ionization chamber, EBT3 films, silicon diodes, MOSFETs, LiF crystals, and alanine dosimetry.
- Conducted measurements at approximately 1 meter from the beam line exit window.
- Evaluated beam characteristics up to a maximum energy of 24.1 MeV.
Main Results:
- Achieved beam reproducibility within 5%.
- Demonstrated beam homogeneity within 4% over a 16 mm diameter circular area.
- Confirmed suitability of the beam energy (up to 24.1 MeV) for radiobiological research.
Conclusions:
- The developed proton linear accelerator shows promising beam characteristics for clinical applications.
- The system's homogeneity and reproducibility meet essential criteria for effective proton therapy.
- Further development will focus on reaching the full 150 MeV energy target for advanced tumor treatments.
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