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Related Concept Videos

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Related Experiment Video

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Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
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Longitudinal autoantibody responses against tumor-associated antigens decrease in breast cancer patients according to

Rick L Evans1, James V Pottala2, Satoshi Nagata3

  • 1Cancer Biology Research Center, Sanford Research, Sioux Falls, SD, USA.

BMC Cancer
|February 2, 2018
PubMed
Summary

Treatment combinations including radiation significantly reduced autoantibody levels against specific tumor-associated antigens (TAAs) in breast cancer patients post-surgery. Radiation therapy was key in altering these autoantibody responses over 12 months.

Keywords:
AutoantibodiesBreast cancerTreatment modalitiesTumor-associated antigens

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Area of Science:

  • Oncology
  • Immunology
  • Biomarker Discovery

Background:

  • Metastatic breast cancer (BCa) diagnosis often occurs late, after symptom onset, with limited routine screening beyond physical exams.
  • Autoantibodies against tumor-associated antigens (TAAs) show potential for early BCa detection.
  • Changes in autoantibody levels during and after BCa treatment remain largely uncharacterized.

Purpose of the Study:

  • To investigate the longitudinal changes in autoantibody levels against TAAs in breast cancer patients during and after treatment.
  • To determine the impact of various treatment regimens on these autoantibody responses.

Main Methods:

  • Collected serial blood samples from 200 BCa patients at three time points: pre-treatment, 6 months post-surgery, and 12 months post-surgery.
  • Assayed autoantibody responses against 32 TAAs using a Luminex multiplex bead assay.
  • Categorized patients based on treatment regimens (surgery, chemotherapy, radiation, trastuzumab, hormonal therapy).

Main Results:

  • Treatment combinations involving radiation therapy (radiation + hormonal therapy, radiation + chemotherapy, radiation + hormonal therapy + chemotherapy) led to significant decreases in autoantibody responses against 9 specific TAAs by 12 months post-surgery.
  • Radiation therapy was identified as the common factor in treatment groups showing significant autoantibody level changes.
  • One TAA, GRP78, exhibited a significant increase in autoantibody response at 12 months post-surgery.

Conclusions:

  • Combined treatments including radiation significantly alter autoantibody profiles in breast cancer patients.
  • Single treatment modalities did not substantially change autoantibody levels.
  • Radiation therapy plays a crucial role in modulating autoantibody responses against TAAs following breast cancer treatment.