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Related Experiment Video

Updated: Feb 15, 2026

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice

A Multiple Integrated Social Stress Model for Psychiatric Disorders in Female C57BL/6J Mice

Published on: July 15, 2025

Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms.

Xinyuan Wang^1,2, Kimberly M Christian¹, Hongjun Song^1,3,4,5

¹Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Genome Medicine

|February 2, 2018

Summary

This summary is machine-generated.

Synaptic dysfunction is a key factor in neuropsychiatric diseases. Research uses genetic studies and advanced models to investigate these synaptic and biological pathways.

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Developing a Behavioral Box for Assessing Prepulse Inhibition and Neural Activity in Psychiatric Animal Models

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Published on: July 22, 2025

Area of Science:

Neuroscience
Genetics
Stem Cell Biology

Background:

Emerging evidence links synaptic dysfunction to the etiology of neuropsychiatric disorders.
Genetic studies have revealed novel biological and synaptic pathways involved in these conditions.

Purpose of the Study:

To investigate the role of synaptic dysfunction in neuropsychiatric diseases.
To explore genetic variants and biological pathways contributing to these disorders.

Main Methods:

Utilizing genetic studies to identify disease-associated variants.
Employing animal models for mechanistic investigations.
Leveraging patient-derived induced pluripotent stem cell (iPSC) models.

Main Results:

Identification of genetic variants impacting synaptic function.
Elucidation of novel biological and synaptic pathways.
Mechanistic insights into synaptic dysfunction in disease.

Conclusions:

Synaptic dysfunction is a significant causal factor in neuropsychiatric diseases.
Genetic and cellular models provide powerful tools for understanding these complex disorders.