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Cisplatin-induced syndrome of inappropriate antidiuretic hormone secretion (SIADH) with life-threatening
1Department of Medical Oncology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Abstract:
We present a case of cisplatin-induced syndrome of inappropriate antidiuretic hormone (SIADH) in a patient with metastatic recurrent urothelial carcinoma. Cisplatin-induced SIADH is an uncommon but potentially life-threatening toxicity. Pharmacogenetic characteristics may result in different toxicity profiles in different populations. With such widespread use of cisplatin in a diverse range of cancers, prompt recognition is crucial to detect and prevent severe neurological sequelae.
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