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Published on: September 10, 2021
Synthetic Studies on Heteropolycyclic Natural Products: Development of Divergent Strategy
1Graduate School of Pharmaceutical Sciences, Nagoya University.
Abstract:
The divergent total syntheses of three types of heteropolycyclic natural products, namely gelsedine-type alkaloids, amathaspiramide alkaloids, and erythrina alkaloids, are outlined. A strategy involving a late-stage pluripotent common synthetic intermediate prepared via original and innovative transformations was employed. A brief description of the philosophy and criteria for choosing the synthetic targets and common synthetic precursors, as well as details regarding the development of the overall synthetic schemes from a common intermediate are discussed.
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