Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

General Properties of Solutions02:12

General Properties of Solutions

36.2K
Many common substances around us exist as a solution, such as ocean water, air, and gasoline. All solutions are mixtures of substances that are composed of varying amounts of two or more types of atoms or molecules. A mixture with a non-uniform composition is a heterogeneous mixture, whereas a mixture with a uniform composition is a homogeneous mixture. The components that make the homogeneous mixture are evenly spread out and thoroughly mixed. 
36.2K
Electrophilic Aromatic Substitution: Sulfonation of Benzene01:22

Electrophilic Aromatic Substitution: Sulfonation of Benzene

8.4K
Sulfonation of benzene is a reaction wherein benzene is treated with fuming sulfuric acid at room temperature to produce benzenesulfonic acid. Fuming sulfuric acid is a mixture of sulfur trioxide and concentrated sulfuric acid.
8.4K
Phase Diagrams02:39

Phase Diagrams

50.5K
A phase diagram combines plots of pressure versus temperature for the liquid-gas, solid-liquid, and solid-gas phase-transition equilibria of a substance. These diagrams indicate the physical states that exist under specific conditions of pressure and temperature and also provide the pressure dependence of the phase-transition temperatures (melting points, sublimation points, boiling points). Regions or areas labeled solid, liquid, and gas represent single phases, while lines or curves represent...
50.5K
Phase Transitions02:31

Phase Transitions

23.3K
Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
23.3K
Ideal Solutions02:24

Ideal Solutions

22.7K
According to Raoult’s law, the partial vapor pressure of a solvent in a solution is equal or identical to the vapor pressure of the pure solvent multiplied by its mole fraction in the solution. However, Raoult's Law is only valid for ideal solutions. For a solution to be ideal, the solvent-solute interaction must be just as strong as a solvent-solvent or solute-solute interaction. This suggests that both the solute and the solvent would use the same amount of energy to escape to the...
22.7K
Dehydration Synthesis01:15

Dehydration Synthesis

150.6K
Overview
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
150.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intracellular delivery of full-length antibodies via organ-targeted lipid nanoparticles.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Intramolecular bonding as a design strategy for robust intermolecular binding of oligomers.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Uncovering the Subtleties of Solvation and Speciation of Organic Halide Salts in Organic Solvents.

The journal of physical chemistry. B·2026
Same author

Correction to "Detection of Mutation-Induced Conformational Changes in an Intrinsically Disordered Protein by Double Quantum Coherence Electron Spin Resonance Methodology".

Journal of the American Chemical Society·2026
Same author

Detection of Mutation-Induced Conformational Changes in an Intrinsically Disordered Protein by Double Quantum Coherence Electron Spin Resonance Methodology.

Journal of the American Chemical Society·2026
Same author

Sulfur-containing class of broad-spectrum antivirals improves influenza virus vaccine development.

Nature communications·2026

Related Experiment Video

Updated: Feb 15, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
11:37

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

19.8K

Synthesis and Solution-Phase Characterization of Sulfonated Oligothioetheramides.

Joseph S Brown1, Yaset M Acevedo1, Grace D He1

  • 1Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14850, United States.

Macromolecules
|February 2, 2018
PubMed
Summary
This summary is machine-generated.

Researchers studied flexible sulfonated oligothioetheramides (oligo-TEAs) to understand how chemical sequence dictates macromolecular structure and dynamics. Backbone hydrophobicity drives entropic collapse, offering insights for designing new functional macromolecules.

More Related Videos

Synthesis and Characterization of Amphiphilic Gold Nanoparticles
10:09

Synthesis and Characterization of Amphiphilic Gold Nanoparticles

Published on: July 2, 2019

18.3K
Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
15:22

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization

Published on: April 3, 2014

17.7K

Related Experiment Videos

Last Updated: Feb 15, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
11:37

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

19.8K
Synthesis and Characterization of Amphiphilic Gold Nanoparticles
10:09

Synthesis and Characterization of Amphiphilic Gold Nanoparticles

Published on: July 2, 2019

18.3K
Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
15:22

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization

Published on: April 3, 2014

17.7K

Area of Science:

  • Biophysical Chemistry
  • Polymer Science
  • Chemical Biology

Background:

  • Macromolecular structure and dynamics are crucial for understanding binding and recognition.
  • Chemical sequence is a key determinant of macromolecular properties.
  • Flexible synthetic polymers offer potential for novel biological applications.

Purpose of the Study:

  • To synthesize and characterize flexible sulfonated oligothioetheramides (oligo-TEAs).
  • To elucidate the room temperature structure and dynamics of oligo-TEAs in water.
  • To investigate the influence of synthetic length, charge, and hydrophobicity on oligo-TEA behavior.

Main Methods:

  • Variable temperature pulse field gradient (PFG) NMR spectroscopy.
  • Double electron-electron resonance (DEER) measurements.
  • Molecular dynamics (MD) simulations.
  • Stokes-Einstein-Sutherland diffusion theory.

Main Results:

  • Significant entropic collapse observed, primarily driven by backbone hydrophobicity.
  • Backbone modifications had a greater impact on structure than pendant groups.
  • Screening of intramolecular electrostatic repulsions was detected.
  • Combined DEER and PFG NMR data provided insights into diffusion.

Conclusions:

  • Oligo-TEAs exhibit sequence-dependent structural and dynamic properties.
  • Backbone hydrophobicity is a critical factor in governing macromolecular conformation.
  • This characterization approach enables de novo design of functional macromolecules.
  • Understanding sequence-structure-function relationships is key for developing new biomaterials.