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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
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Lactococcus lactis As a Versatile Vehicle for Tolerogenic Immunotherapy
Dana P Cook1, Conny Gysemans1, Chantal Mathieu1
1Laboratory of Clinical and Experimental Endocrinology (CEE), KU Leuven, Leuven, Belgium.
Frontiers in Immunology
|February 2, 2018
Summary
Genetically modified Lactococcus lactis bacteria are safe, effective live biofactories for delivering therapeutic proteins to mucosal tissues. This approach shows promise for treating autoimmune diseases like type 1 diabetes by inducing immune tolerance.
Area of Science:
- Microbiology
- Immunology
- Biotechnology
Background:
- Genetically modified Lactococcus lactis (L. lactis) offers a safe platform for delivering bioactive proteins to mucosal tissues.
- L. lactis has a strong safety profile due to its history of human consumption and lack of toxicity or immunogenicity.
- Containment strategies enhance L. lactis's potential for clinical applications as protein-based therapeutics.
Purpose of the Study:
- To review technological advancements in L. lactis as live biofactories.
- To discuss L. lactis-mediated mucosal drug delivery for tolerogenic immunotherapies.
- To highlight L. lactis's role in inducing mucosal tolerance for autoimmune disease treatment.
Main Methods:
- Review of technological advancements in L. lactis engineering.
- Discussion of L. lactis-mediated mucosal drug delivery systems.
- Analysis of L. lactis applications in inducing immune tolerance.
Main Results:
- L. lactis has been enhanced as a versatile live biofactory for protein delivery.
- L. lactis facilitates mucosal drug delivery for various immunotherapies.
- Targeted autoantigen delivery via L. lactis in the intestine can reverse autoimmune type 1 diabetes.
Conclusions:
- Genetically modified L. lactis represents a promising platform for developing novel protein-based therapeutics.
- Mucosal delivery via L. lactis is effective for inducing local and systemic immune effects.
- L. lactis holds significant potential for treating autoimmune diseases through targeted immunotherapy.
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