Related Experiment Video
Updated: Feb 15, 2026
07:20
Human Colonoid Monolayers to Study Interactions Between Pathogens, Commensals, and Host Intestinal Epithelium
Published on: April 9, 2019
9.8K
Exploring Host-Commensal Interactions in the Respiratory Tract.
Sudhanshu Shekhar1, Karl Schenck1, Fernanda Cristina Petersen1
1Faculty of Dentistry, Department of Oral Biology, University of Oslo, Oslo, Norway.
Frontiers in Immunology
|February 2, 2018
Summary
Commensal microbes in the respiratory tract are crucial for health and disease. Understanding their interaction with the immune system can lead to new vaccines and therapeutics.
Area of Science:
- Microbiology
- Immunology
- Biomedical Research
Background:
- Commensal microbes are vital for human health and disease.
- Humans host diverse commensals, particularly in the gut and respiratory tracts.
- Omics technologies and animal models enhance understanding of host-commensal interactions.
Purpose of the Study:
- To review host responses to respiratory commensals.
- To explore immune cross-reactivity between commensals and pathogens.
- To examine the potential of commensals as vaccine delivery systems.
Main Methods:
- Review of human and animal studies.
- Analysis of host-commensal interactions.
- Exploration of immunological responses.
Main Results:
- Emerging data highlight host responses to respiratory commensals.
- Immune cross-reactivity between commensals and pathogens is observed.
- Commensals show potential as vaccine delivery platforms.
Conclusions:
- Further understanding of host-commensal interplay is needed.
- This knowledge can inform the development of novel vaccines and therapeutics.
- Focus on respiratory tract commensals is increasing.
Related Concept Videos
01:31Anatomy of Respiratory System II: Lower Respiratory Tract
4.1K
The lower respiratory tract is anatomically composed of several vital structures, including the larynx, trachea, bronchial tree, alveoli, lungs, and pleurae. Each component has a specific function, and all are intricately connected to ensure efficient respiration.
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
4.1K
01:29Anatomy of Respiratory System I: Upper Respiratory Tract
5.5K
The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract....
5.5K
01:27Physical Assessment of the Respiratory Tract II: Inspection
950
Physical assessment of the respiratory tract through inspection is a crucial step in understanding the patient's respiratory health. It provides insights into the functioning of the respiratory system, the musculoskeletal structure, and even the patient's nutritional status. This comprehensive approach involves observing several vital aspects: chest configuration, breathing patterns, respiratory rates, skin color, and use of accessory muscles.
Chest Configuration
The chest configuration...
Chest Configuration
The chest configuration...
950
01:24Physical Assessment of the Respiratory Tract II: Palpation
2.1K
Physical assessment of the respiratory tract is critical in identifying potential health issues. One key component of this assessment is palpation, a technique healthcare providers use to assess the body for abnormalities. This content explores the method of palpation in evaluating the respiratory tract, focusing on thoracic palpation and tactile fremitus.
Thoracic Palpation
Thoracic palpation detects tenderness, masses, lesions, respiratory excursions, and vocal fremitus. The nurse assesses...
Thoracic Palpation
Thoracic palpation detects tenderness, masses, lesions, respiratory excursions, and vocal fremitus. The nurse assesses...
2.1K
01:28Physical Assessment of the Respiratory Tract I: Health History
949
Physical assessment of the respiratory tract is critical to patient care. It allows healthcare professionals to identify and manage various respiratory conditions. The process involves a combination of subjective and objective data collection.
Subjective Data
Subjective data provides vital information about the patient's health history and symptoms. This data is typically collected through interviews in which patients describe their experiences, symptoms, and concerns.
Health history and...
Subjective Data
Subjective data provides vital information about the patient's health history and symptoms. This data is typically collected through interviews in which patients describe their experiences, symptoms, and concerns.
Health history and...
949
01:29Physical Assessment of the Respiratory Tract III: Percussion
3.4K
The respiratory system, fundamental to life, consists of complex structures responsible for gas exchange. The percussion assessment is critical to understanding this system's health and functionality. This non-invasive assessment technique allows healthcare providers to evaluate the density or aeration of the lungs, thereby identifying potential abnormalities.
Percussion in Respiratory Assessment
Percussion evaluates underlying tissue composition with audible and tactile vibrations,...
Percussion in Respiratory Assessment
Percussion evaluates underlying tissue composition with audible and tactile vibrations,...
3.4K