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Ageing: from inflammation to cancer
Giulia C Leonardi1, Giulia Accardi2, Roberto Monastero3
11Department of Biomedical and Biotechnological Sciences, Pathology and Oncology Section, University of Catania, Catania, Italy.
Immunity & Ageing : I & A
|February 2, 2018
Summary
Aging significantly increases cancer risk, driven by inflammaging, a chronic inflammation. This review explores how age-related inflammation pathways connect to cancer development, from initiation to metastasis.
Area of Science:
- Gerontology
- Oncology
- Immunology
Background:
- Aging is the primary risk factor for cancer.
- Inflammaging, a chronic, low-grade systemic inflammation, characterizes aging.
- Inflammation is a known hallmark of cancer, affecting all stages.
Purpose of the Study:
- To review molecular and cellular pathways of age-related chronic inflammation (inflammaging).
- To explore potential triggers of inflammaging.
- To connect inflammaging pathways and triggers to cancer development.
Main Methods:
- Literature review of molecular and cellular pathways.
- Analysis of age-related inflammation triggers.
- Synthesis of evidence linking inflammation to cancer.
Main Results:
- Inflammaging involves specific molecular and cellular pathways.
- Various factors can trigger age-related chronic inflammation.
- These pathways and triggers are demonstrably linked to cancer initiation and progression.
Conclusions:
- Inflammaging is a key biological link between aging and cancer.
- Understanding these pathways offers potential therapeutic targets.
- Targeting inflammaging may mitigate age-related cancer risk.
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