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Effects on Sperms' Quality of Selegiline in Aged Rats
Huba Kalász1, Julianna Thuróczy2, Gellért Karvaly3
1Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary.
The Open Medicinal Chemistry Journal
|February 2, 2018
Abstract
Background:
Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered.
Objective:
Scouting special and beneficial side effects of selegiline treatment.
Method:
Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks' treatment.
Results:
Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased.
Conclusion:
Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.