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Body mass index as a risk factor for coronary events and mortality in patients with type 1 diabetes

Daniel Vestberg1,2, Annika Rosengren2, Katarina Eeg-Olofsson2

  • 1Department of Medicine, NU-Hospital Organization, Trollhättan, Sweden.

Open Heart
|February 2, 2018
PubMed

Insights

In type 1 diabetes, higher body mass index (BMI) does not increase myocardial infarction or coronary death risk. However, low BMI (underweight) is linked to higher mortality risks in these patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Diabetes Research

Background:

  • Type 1 diabetes (T1D) management involves monitoring cardiovascular risk factors.
  • The role of body mass index (BMI) in cardiovascular outcomes for T1D patients requires clarification.

Purpose of the Study:

  • To examine the association between BMI and the risk of myocardial infarction (MI) and coronary death in individuals with T1D.

Main Methods:

  • A cohort of 17,499 T1D patients from the Swedish National Diabetes Registry (2002-2011) was analyzed.
  • Cox regression models were employed to assess the relationship between BMI categories and cardiovascular events/mortality.

Main Results:

  • Elevated BMI (≥35 kg/m²) was not significantly associated with an increased risk of MI.
  • No significant link was found between BMI and coronary mortality, acute coronary events, or all-cause mortality after adjustments.
  • Underweight patients (BMI <18.5 kg/m²) exhibited a significantly higher hazard for both coronary and all-cause mortality.

Conclusions:

  • Increased BMI is not an independent risk factor for myocardial infarction or coronary death in type 1 diabetes patients.
  • Low BMI (underweight) is a significant predictor of increased mortality (coronary and all-cause) in this population.
Abstract

Keywords:
coronary artery diseasediabetic heart diseaseepidemiology

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