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Updated: Feb 15, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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High brain serotonin levels in migraine between attacks: A 5-HT4 receptor binding PET study

Marie Deen1, Hanne D Hansen2, Anders Hougaard3

  • 1Danish Headache Center, Department of Neurology, Rigshospitalet, DK-2600 Glostrup, Denmark; Neurobiology Research Unit and NeuroPharm, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark; Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark; Center for Experimental Medicine Neuropharmacology, Department of Neurology, Rigshospitalet, DK-2100 Copenhagen, Denmark.

Neuroimage. Clinical
|February 2, 2018
PubMed
Summary

Migraine patients show lower 5-HT4 receptor binding, suggesting higher brain serotonin levels, contrary to common belief. This finding may indicate a trait or consequence of migraine.

Keywords:
BrainHeadacheNeuroimagingPainSerotonergic mechanisms

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