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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.2K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
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Related Experiment Video

Updated: Feb 15, 2026

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
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Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

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Psoriasis and inflammatory bowel disease: links and risks.

Christoforos Vlachos1, Georgios Gaitanis1, Konstantinos H Katsanos2

  • 1Department of Skin and Venereal Diseases.

Psoriasis (Auckland, N.Z.)
|February 2, 2018
PubMed
Summary

Psoriasis and inflammatory bowel diseases (IBD) share genetic links and immune pathways, particularly involving dendritic and Th17 cells. Treatments overlap, but distinct differences remain, requiring tailored therapeutic strategies.

Keywords:
Crohn’s diseaseimmune cellsinflammationinflammatory bowel diseasepsoriasisulcerative colitis

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DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

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Area of Science:

  • Immunology
  • Gastroenterology
  • Dermatology

Background:

  • Psoriasis and inflammatory bowel diseases (IBD) are chronic inflammatory conditions with overlapping epidemiology and genetics.
  • Shared genetic loci and polymorphisms suggest a common underlying susceptibility.
  • Increased barrier permeability in skin and gut facilitates immune cell activation.

Purpose of the Study:

  • To comprehensively compare risk factors, pathogenesis, and therapeutic strategies for psoriasis and IBD.
  • To elucidate the shared and distinct roles of immune cells and mediators in disease development.
  • To review current and emerging therapeutic approaches for these related conditions.

Main Methods:

  • Review of existing literature on psoriasis and IBD.
  • Analysis of genetic, immunologic, and clinical data.
  • Comparison of pathogenetic mechanisms and treatment outcomes.

Main Results:

  • Psoriasis and IBD share common immune pathways, including the involvement of dendritic cells and Th17 cells.
  • Shared susceptibility loci and polymorphisms confirm a genetic link.
  • Therapeutic strategies show significant overlap, particularly with immunomodulators and biologics targeting cytokines.

Conclusions:

  • The pathogenesis of psoriasis and IBD involves similar immune dysregulation, leading to overlapping therapeutic strategies.
  • Despite similarities, distinct pathophysiologic differences necessitate tailored treatments for skin and gut manifestations.
  • Further research into shared and unique pathways can optimize therapeutic interventions for both conditions.