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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Pustular psoriasis: pathophysiology and current treatment perspectives.

Katie E Benjegerdes1, Kimberly Hyde2, Dario Kivelevitch3

  • 1Texas A&M Health Science Center College of Medicine, Temple.

Psoriasis (Auckland, N.Z.)
|February 2, 2018
PubMed
Summary

Pustular psoriasis variants are rare chronic inflammatory skin conditions with diverse presentations. While challenging to treat, emerging immunomodulatory therapies offer future treatment promise.

Keywords:
acrodermatitis continua of Hallopeaubiologicgeneralized pustular psoriasisimpetigo herpetiformispalmoplantar pustulosispsoriasispustular psoriasisvon Zumbusch

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Area of Science:

  • Dermatology
  • Immunology

Background:

  • Psoriasis vulgaris is a chronic inflammatory disease affecting skin and joints, often with comorbidities.
  • Pustular psoriasis encompasses uncommon generalized and localized subtypes with distinct clinical presentations but shared histopathology.

Purpose of the Study:

  • To review the clinical subtypes, immunopathogenesis, and treatment challenges of pustular psoriasis variants.
  • To highlight the potential of novel immunomodulatory therapies for these rare conditions.

Main Methods:

  • Literature review of clinical presentations and histopathology of pustular psoriasis subtypes.
  • Discussion of current understanding of immunopathogenesis and treatment outcomes.
  • Exploration of emerging biologic and immunomodulatory treatment strategies.

Main Results:

  • Pustular psoriasis variants include generalized (acute, pregnancy, infantile/juvenile) and localized (acrodermatitis continua of Hallopeau, palmoplantar) forms.
  • The immunopathogenesis of these variants is not fully understood, and their classification relative to psoriasis vulgaris is debated.
  • Variable treatment results are common due to rarity and unclear links to plaque psoriasis, making them difficult to manage.

Conclusions:

  • Pustular psoriasis variants represent a spectrum of inflammatory dermatoses requiring further research into their pathogenesis.
  • Biologic and immunomodulatory therapies show promise for improving treatment outcomes in these rare conditions.