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Drug-induced psoriasis: clinical perspectives
Deepak Mw Balak1, Enes Hajdarbegovic1
1Department of Dermatology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Psoriasis (Auckland, N.Z.)
|February 2, 2018
Summary
Certain medications can trigger or worsen psoriasis. Identifying drug-induced psoriasis is challenging but crucial for management, involving drug cessation and standard psoriasis treatments.
Area of Science:
- Dermatology
- Pharmacology
- Immunology
Background:
- Drug exposure can induce or exacerbate psoriasis.
- Associations exist with beta-blockers, lithium, antimalarials, and interferons.
- Newer targeted therapies (e.g., TNF-alpha antagonists, immune checkpoint inhibitors) are also implicated.
Purpose of the Study:
- To highlight the clinical relevance of recognizing drug-related psoriasis.
- To discuss challenges in identifying medication-induced psoriasis.
- To outline management strategies for drug-related psoriasis.
Main Methods:
- Review of existing literature on drug-induced psoriasis.
- Discussion of clinical and histopathological features.
- Mention of the Naranjo scale for assessing causality.
Main Results:
- Drug-related psoriasis can mimic classical forms, with variable latency periods.
- Cessation of the offending drug is the primary management step.
- Psoriatic lesions may persist post-withdrawal, requiring conventional treatments.
Conclusions:
- Recognizing drug-induced psoriasis is vital for patient management.
- Differentiating drug-related from classical psoriasis can be difficult.
- Management involves drug withdrawal and standard psoriasis therapies.
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