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Microbial treatment in chronic constipation.

Linsheng Huang1,2, Qi Zhu1, Xiao Qu1

  • 1Department of General Surgery, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, 200072, China.

Science China. Life Sciences
|February 2, 2018
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Summary
This summary is machine-generated.

Microbial treatments, including fecal microbiota transplantation (FMT), offer a safe and effective alternative for chronic functional constipation by restoring gut flora and improving symptoms.

Keywords:
FMTconstipationprebioticsprobioticssynbiotics

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Area of Science:

  • Gastroenterology
  • Microbiology
  • Internal Medicine

Background:

  • Chronic functional constipation is a prevalent condition affecting all age groups, leading to significant physiological and psychological distress.
  • Current treatments like purgatives and surgery often disrupt normal intestinal function.
  • Emerging research highlights the link between gut microbiota disturbances and constipation, paving the way for microbial therapies.

Purpose of the Study:

  • To review the efficacy of microbial treatments for chronic functional constipation.
  • To compare microbial therapies with traditional treatment methods.
  • To assess the potential of microbial interventions in clinical practice.

Main Methods:

  • Review of current literature on microbial treatments for chronic functional constipation.
  • Analysis of probiotic preparations, prebiotics, synbiotics, and fecal microbiota transplantation (FMT).
  • Comparison of safety, convenience, and curative effects of microbial versus traditional therapies.

Main Results:

  • Microbial treatments, particularly FMT, demonstrate high curative effects and safety.
  • These therapies improve clinical symptoms and promote the recovery of intestinal flora.
  • No complications were reported during microbial treatment processes.

Conclusions:

  • Microbial treatments offer significant advantages over traditional methods for chronic functional constipation.
  • Probiotic preparations and FMT are effective, safe, and convenient therapeutic options.
  • Further clinical research and application of microbial treatments are warranted.