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Liponeurofibroma: Clinicopathological features and histogenesis
Solam Lee1, Hana Bak1, Sung Ku Ahn1
1Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.
The Journal of Dermatology
|February 2, 2018
Summary
Liponeurofibroma, a fatty variant of neurofibroma, is more common in older females with neurofibromatosis type 1. Its distinct features and histogenesis require further study.
Area of Science:
- Dermatopathology
- Oncology
- Histology
Background:
- Neurofibromas are common benign neural tumors.
- Fatty variants, or liponeurofibromas, are rare and poorly understood.
- Clinicopathological features of liponeurofibromas need further investigation.
Purpose of the Study:
- To investigate liponeurofibroma, a rare fatty variant of neurofibroma.
- To identify distinctive clinicopathological features and histogenesis.
- To compare liponeurofibroma with the classic neurofibroma.
Main Methods:
- Retrospective analysis of 130 neurofibroma cases.
- Immunohistochemical staining (S100, factor VIIIa, perilipin, VEGF).
- Masson's trichrome stain and transmission electron microscopy for adipocytes.
Main Results:
- 32 cases (24.6%) were classified as liponeurofibroma.
- Liponeurofibroma was more frequent in neurofibromatosis type 1, older age, and females.
- Head and neck were the most common locations; intratumoral fat differed from subcutaneous fat.
Conclusions:
- Liponeurofibroma exhibits distinct clinicopathological features.
- Neurofibromatosis type 1 is associated with increased odds of fatty change.
- Pathomechanisms of fatty change in liponeurofibromas warrant further research.
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