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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease II: Clinical Manifestations01:24

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Chronic Obstructive Pulmonary Disease01:24

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COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
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Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
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Related Experiment Video

Updated: Feb 15, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Leptin and chronic kidney diseases.

Song Mao1, Li Fang1, Fen Liu1

  • 1a Department of Pediatrics , Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai , China.

Journal of Receptor and Signal Transduction Research
|February 2, 2018
PubMed
Summary

Leptin, a hormone involved in metabolism, has a complex and unclear role in chronic kidney diseases (CKD). Understanding leptin

Keywords:
Chronic kidney diseasesleptinprognosis

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Area of Science:

  • Nephrology and Endocrinology
  • Metabolic disorders and kidney function

Background:

  • Chronic kidney diseases (CKD) present significant economic burdens due to refractory complications.
  • Metabolic disorders are key factors influencing clinical outcomes in CKD.
  • Leptin, a hormone from adipose tissue, regulates energy balance and impacts immunity and hematopoiesis.

Purpose of the Study:

  • To elucidate the precise and multifaceted role of leptin in the context of chronic kidney diseases.
  • To explore the interactions between leptin and other signaling molecules in CKD pathogenesis.

Main Methods:

  • Literature review synthesizing current research on leptin's function in kidney disease.
  • Analysis of studies investigating leptin levels and effects in various nephritis and glomerular disorders.
  • Exploration of leptin's influence on metabolic and immune pathways relevant to CKD.

Main Results:

  • Elevated leptin levels are frequently observed in patients with CKD.
  • Leptin deficiency can impair immune responses in nephritis, while leptin may inhibit obesity-associated glomerular damage.
  • The exact contribution of leptin to CKD progression and complications remains incompletely understood.

Conclusions:

  • Leptin's role in CKD is complex, with potential protective and detrimental effects depending on the context.
  • Further research is needed to fully integrate the understanding of leptin's interactions in CKD.
  • Clarifying leptin's function could reveal novel therapeutic targets for managing CKD complications.