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Updated: Feb 15, 2026

Activating Autophagy by Aerobic Exercise in Mice
Published on: February 3, 2017
Karyoptosis: A novel type of cell death caused by chronic autophagy inhibition
1a Department of Basic and Clinical Neuroscience , King's College London , London , UK.
Abstract:
Macroautophagy/autophagy influences onset and progression of several human neurodegenerative diseases, because of its critical role as a regulator of neuronal proteostasis and organelle quality control. In many neurodegenerative diseases, impairment in autophagy is thought to play a fundamental part in the terminal phases of cellular degeneration and death. However, the ultimate mechanism of neuronal cell death remains elusive. In a recent study we have identified a new form of regulated cell death, which arises upon autophagy inhibition.
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