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Effect of polymeric IgG on human accessory cell function.

J W Mannhalter, R Ahmad, H Pinzker

    Clinical Immunology and Immunopathology
    |June 1, 1986
    PubMed
    Summary
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    Polymeric IgG significantly impairs monocytes' antigen presentation capacity by affecting their cell membrane, not by inducing suppressors. This impacts host defense without hindering other immune functions.

    Area of Science:

    • Immunology
    • Cell Biology

    Background:

    • Circulating immune complexes influence host defense and immune response modulation.
    • Polymeric IgG serves as a model for immune complexes in studying monocyte function.

    Purpose of the Study:

    • To investigate the effect of polymeric IgG on human monocyte accessory functions.
    • To determine how polymeric IgG influences antigen presentation by monocytes.

    Main Methods:

    • Incubation of human monocytes with polymeric IgG.
    • Assessment of antigen-presenting capacity via T cell proliferation.
    • Analysis of suppressor mechanisms, interleukin-1 release, and MHC class II expression.

    Main Results:

    • A 1-hour incubation with polymeric IgG significantly decreased monocyte antigen presentation.

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  • Accessory functions in alloantigen- or mitogen-driven proliferation remained unaffected.
  • No evidence of suppressor factor generation or induction of suppressive monocytes was found.

    • Conclusions:

    • Polymeric IgG impairs monocyte antigen presentation, likely due to plasma membrane changes and altered MHC class II reexpression kinetics.
    • This impairment affects host defense mechanisms without compromising other monocyte accessory functions.