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Steroid-resistant nephrotic syndrome: past and current perspectives
Noureddin Nourbakhsh1, Robert H Mak1
1Division of Pediatric Nephrology, Rady Children's Hospital San Diego, University of California, San Diego, La Jolla, CA, USA.
Pediatric Health, Medicine and Therapeutics
|February 2, 2018
Summary
Steroid-resistant nephrotic syndrome (SRNS) presents treatment challenges and risks kidney failure. This review covers SRNS history, biopsy, genetics, and therapies for better patient outcomes.
Area of Science:
- Nephrology
- Genetics
- Pathology
Background:
- Steroid-resistant nephrotic syndrome (SRNS) affects patients unresponsive to standard immunosuppression.
- SRNS patients face a heightened risk of progressing to end-stage renal disease.
- Effective SRNS management necessitates understanding its history, pathology, and genetic underpinnings.
Purpose of the Study:
- To provide a comprehensive review of steroid-resistant nephrotic syndrome (SRNS).
- To appraise the historical context, diagnostic role of renal biopsy, genetic factors, and therapeutic strategies for SRNS.
Main Methods:
- Literature review focusing on historical treatments, renal histopathology, and genetic studies in SRNS.
- Synthesis of current knowledge on SRNS diagnosis and management.
Main Results:
- SRNS is a complex condition with diverse etiologies.
- Genetics plays a significant role in a subset of SRNS cases.
- Renal biopsy remains crucial for diagnosis and guiding treatment.
Conclusions:
- Understanding the history, genetics, and pathology of SRNS is vital for appropriate treatment.
- Personalized therapeutic approaches based on underlying causes improve SRNS patient outcomes.
- Further research into SRNS genetics and novel therapies is warranted.
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