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Polyacrylamide Gels for Invadopodia and Traction Force Assays on Cancer Cells
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Variation in traction forces during cell cycle progression.

Benoit Vianay1, Fabrice Senger2, Simon Alamos3

  • 1University of Paris Diderot, INSERM, CEA, Hôpital Saint Louis, Institut Universitaire d'Hematologie, UMRS1160, CytoMorpho Lab, 75010, Paris, France.

Biology of the Cell
|February 2, 2018
PubMed
Summary
This summary is machine-generated.

Cellular traction forces change non-monotonously during the cell cycle, increasing in early phases and decreasing in later ones. This biphasic behavior is regulated by cell signaling, impacting tissue homeostasis.

Keywords:
Cell cycleCell mechanicsTraction forces

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Area of Science:

  • Cell Biology
  • Biophysics
  • Mechanobiology

Background:

  • Tissue morphogenesis relies on cell growth and mechanical forces.
  • The influence of forces on cell proliferation is known, but the inverse is less understood.
  • Investigating how cell traction forces change during the cell cycle is crucial.

Purpose of the Study:

  • To determine how cell traction forces vary throughout the cell cycle.
  • To understand the relationship between cell contractility and cell cycle progression.
  • To elucidate the role of cell signaling in regulating contractility.

Main Methods:

  • Constraining cell shape on micropatterned substrates.
  • Measuring traction forces in asynchronously dividing cells.
  • Utilizing a cell-cycle reporter for precise timing.

Main Results:

  • Cellular traction forces increase during the G1 phase.
  • Forces plateau during the S phase.
  • Traction forces decrease during the G2 phase, exhibiting biphasic behavior.

Conclusions:

  • Cell traction forces display a biphasic pattern during the cell cycle, independent of cell size and shape.
  • Cell signaling plays a key role in regulating cell contractility.
  • Non-monotonous contractility variations influence tissue homeostasis mechanoregulation.