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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
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Primary orbital melanoma: a case series and literature review

Edwin Figueira1,2, Saul Rajak1,3, Penny McKelvie4

  • 1a South Australian Institute of Ophthalmology , Royal Adelaide Hospital , Adelaide , Australia.

Orbit (Amsterdam, Netherlands)
|February 2, 2018
PubMed

Insights

Primary orbital melanoma (POM) is rare. Exenteration with radiotherapy offers better disease-free survival compared to wide local excision for this condition.

Area of Science:

  • Ophthalmology
  • Oncology
  • Pathology

Background:

  • Primary orbital melanoma (POM) is an exceptionally rare malignancy.
  • Understanding optimal treatment strategies for POM is crucial due to its rarity and potential for metastasis.

Observation:

  • Four new cases of POM were identified between 2000 and 2013.
  • Patients typically presented with proptosis and diplopia, often without initial visual impairment.
  • Two patients had a history of blue nevi.

Findings:

  • Multicentre review of 4 new and existing literature cases.
  • Primary exenteration with adjuvant radiotherapy showed a higher disease-free survival rate (7/8) compared to wide local excision (7/16).
  • Adjuvant radiotherapy may further enhance outcomes in POM management.

Implications:

  • Exenteration followed by radiotherapy appears to be a more effective treatment for primary orbital melanoma.
  • Early diagnosis and aggressive surgical management are critical for improving patient prognosis.
  • Further research into adjuvant therapies could optimize treatment protocols for this rare orbital tumor.
Keywords:
Adjuvant treatmentblue cellular naevuscongenital ocular melanocytosisexenterationorbitprimary orbital melanoma

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