Related Experiment Video

Updated: Feb 15, 2026

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
09:06

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Published on: January 9, 2019

14.8K

Changes in Otoacoustic Emissions and Auditory Brain Stem Response after C/s-Platinum Exposure in Gerbils

Kathleen C Y Sie1, Susan J Norton1

  • 11 Children's Hospital and Medical Center, Seattle, and the Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, Washington.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|February 2, 2018
PubMed

Insights

Cis-platinum chemotherapy can cause hearing loss by damaging outer hair cells (OHCs). Distortion-product otoacoustic emissions (DPOAE) effectively monitor this ototoxicity, showing significant threshold elevations post-treatment.

Area of Science:

  • Ototoxicology
  • Auditory Neuroscience
  • Pharmacology

Background:

  • Cis-platinum chemotherapy is known to cause ototoxicity, manifesting as hearing loss and tinnitus.
  • Outer hair cells (OHCs) are the primary targets of cis-platinum-induced ototoxicity.
  • Evoked otoacoustic emissions (EOAE) assess OHC function, with distortion-product otoacoustic emissions (DPOAE) offering frequency-specific monitoring.

Purpose of the Study:

  • To evaluate the efficacy of distortion-product otoacoustic emissions (DPOAE) in monitoring cis-platinum ototoxicity.
  • To compare DPOAE threshold changes with auditory brain stem evoked response (ABR) thresholds following cis-platinum administration in gerbils.

Main Methods:

  • Distortion-product otoacoustic emissions (DPOAE) and auditory brain stem evoked response (ABR) thresholds were measured in gerbils before and at 2, 5, and 14 days after a single cis-platinum dose.
  • Control animals received saline.
  • DPOAE were measured at specific frequencies (f2 = 2, 4, 6, 8, 10, 12 kHz).

Main Results:

  • No significant ototoxic effects were observed at the 2-day post-treatment mark.
  • Cis-platinum treated gerbils showed significant elevations in both DPOAE and ABR thresholds at 5 and 14 days compared to controls.
  • No significant difference in threshold changes was found between the 5-day and 14-day groups.

Conclusions:

  • Distortion-product otoacoustic emissions (DPOAE) are sensitive indicators of cis-platinum-induced ototoxicity.
  • DPOAE provide a viable method for tracking outer hair cell damage caused by chemotherapy.
  • Monitoring DPOAE and ABR thresholds can help assess the impact of ototoxic drugs on hearing function.

More Related Videos

Evaluation of Auditory Brainstem Response in Chicken Hatchlings09:32

Evaluation of Auditory Brainstem Response in Chicken Hatchlings

Published on: April 1, 2022

3.6K
Infant Auditory Processing and Event-related Brain Oscillations06:34

Infant Auditory Processing and Event-related Brain Oscillations

Published on: July 1, 2015

17.0K

Related Concept Videos

Pharmacokinetic–Pharmacodynamic Relationship: Exposure, Response and Effect01:26

Pharmacokinetic–Pharmacodynamic Relationship: Exposure, Response and Effect

The pharmacokinetic-pharmacodynamic (PK-PD) relationship describes the intricate link between drug exposure, efficacy, and toxicity, forming the foundation for optimal dosing regimens. This relationship uses mathematical modeling to characterize drug concentration-effect dynamics, ensuring precise therapeutic outcomes.Exposure represents the pharmacokinetic aspect of the PK-PD relationship, denoting the drug amount that elicits a biological response. It is typically quantified by administered...
19
Emission Spectra02:39

Emission Spectra

When solids, liquids, or condensed gases are heated sufficiently, they radiate some of the excess energy as light. Photons produced in this manner have a range of energies, and thereby produce a continuous spectrum in which an unbroken series of wavelengths is present.
76.7K
The Auditory Ossicles01:11

The Auditory Ossicles

The auditory ossicles of the middle ear transmit sounds from the air as vibrations to the fluid-filled cochlea. The auditory ossicles consist of two malleus (hammer) bones, two incus (anvil) bones, and two stapes (stirrups), one on each side. These bones develop during the fetal stage and are the ones to ossify first. They are fully mature at birth and do not grow afterward.
The aptly named stapes look very much like a stirrup. The three ossicles are unique to mammals, and each plays a role in...
3.2K
Auditory Perception01:17

Auditory Perception

The auditory system is essential for sound perception, utilizing various critical structures. When sound waves enter the outer ear, they travel through the ear canal and cause the eardrum to vibrate. These vibrations are then transmitted to the middle ear, where three tiny bones – the malleus, incus, and stapes – amplify the sound. This amplification is crucial, as it ensures that the sound vibrations are strong enough to be conveyed to the inner ear. These vibrations then reach the...
1.2K
Auditory Pathway01:15

Auditory Pathway

Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
7.5K
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
7.7K