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Updated: Feb 15, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
Published on: September 27, 2012
UV-B-Induced Erythema in Human Skin: The Circadian Clock Is Ticking
Soumyadeep Sarkar1, Shobhan Gaddameedhi2
1Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, Washington, USA.
Abstract:
Acute exposure of skin to UV-B causes DNA damage and sunburn erythema in both mice and humans. Previous studies documented time-of-day-related differences in sunburn responses after UV-B exposure in mice. Because humans are diurnal and mice are nocturnal, the circadian rhythm in human skin was hypothesized to be in opposite phase to the rhythm in mice. A study by Nikkola et al. demonstrates that humans are more prone to sunburn erythema after evening exposure to solar UV-B radiation as compared with morning exposure.
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