Related Experiment Video

Updated: Feb 15, 2026

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection
07:39

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection

Published on: January 1, 2017

23.3K

Wnt Signaling in Skeletal Muscle Development and Regeneration

Francesco Girardi1, Fabien Le Grand1

  • 1Sorbonne Universitésy, UPMC Université Paris 06, INSERM UMRS974, Centre of Research in Myology, Paris, France.

Progress in Molecular Biology and Translational Science
|February 2, 2018
PubMed

Insights

Wnt signaling is crucial for muscle development and repair. This review details Wnt

Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cell Signaling

Background:

  • Wnt signaling molecules are vital for embryogenesis, tissue repair, and cancer.
  • Wnt pathways, both canonical and noncanonical, regulate muscle formation and homeostasis.

Purpose of the Study:

  • To provide a comprehensive overview of Wnt signaling in muscle development.
  • To update the understanding of Wnt functions in muscle repair.
  • To discuss the interplay between Wnt and TGFβ signaling in skeletal muscle.

Main Methods:

  • Literature review
  • Synthesis of existing research on Wnt signaling in myogenesis
  • Analysis of Wnt and TGFβ crosstalk in skeletal muscle

Main Results:

  • Wnt signaling plays a significant role throughout muscle development.
  • Wnt pathways are essential for maintaining adult skeletal muscle homeostasis.
  • Complex interactions exist between Wnt and TGFβ signaling in muscle.

Conclusions:

  • Wnt signaling is a key regulator of skeletal muscle development and repair.
  • Understanding Wnt and TGFβ crosstalk is important for muscle biology.
  • Further research into Wnt pathways can inform therapeutic strategies for muscle disorders.
Keywords:
WntWnt/TGFβ crosstalkmuscle regenerationmyofibersmyogenesissatellite cellsskeletal muscle

More Related Videos

Studying Wnt Signaling During Patterning of Conducting Airways13:00

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

7.8K
Author Spotlight: A Cryoinjury Model for Studying Skeletal Muscle Regeneration of the Caudal Peduncle in Adult Zebrafish07:29

Author Spotlight: A Cryoinjury Model for Studying Skeletal Muscle Regeneration of the Caudal Peduncle in Adult Zebrafish

Published on: July 7, 2023

3.4K

Related Concept Videos

Classification of Skeletal Muscle Fibers01:48

Classification of Skeletal Muscle Fibers

Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
59.6K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
10.7K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.5K
Overview of Skeletal Muscle01:15

Overview of Skeletal Muscle

Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
15.0K
Relaxation of Skeletal Muscles01:29

Relaxation of Skeletal Muscles

The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
6.1K
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.0K