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Long Non-Coding RNAs in Multiple Myeloma.

Lucia Nobili1, Domenica Ronchetti2, Luca Agnelli3

  • 1Department of Oncology and Hemato-Oncology, University of Milan, and Hematology, Fondazione Ca' Granda IRCCS Policlinico, 20122 Milan, Italy. lucia.nobili@unim.it.

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Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in multiple myeloma (MM) pathogenesis. This review explores lncRNAs

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expression profilinglong non-coding RNAs (lncRNAs)multiple myeloma (MM)transcription regulation

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Multiple myeloma (MM) is an incurable plasma cell malignancy with largely unknown pathogenesis.
  • Non-coding RNAs (ncRNAs), including microRNAs and long non-coding RNAs (lncRNAs), play critical roles in cancer.
  • lncRNAs are involved in cellular processes and carcinogenesis, with aberrant expression observed in hematological malignancies.

Purpose of the Study:

  • To review the current literature on the role of long non-coding RNAs (lncRNAs) in the pathogenesis of multiple myeloma (MM).
  • To highlight the potential of lncRNAs as diagnostic, prognostic, and therapeutic targets in MM.

Main Methods:

  • Literature review of recent studies on lncRNAs and multiple myeloma.
  • Analysis of lncRNA expression patterns and functional roles in MM pathogenesis.
  • Summary of lncRNAs' potential as biomarkers and therapeutic agents.

Main Results:

  • lncRNAs are aberrantly expressed in MM and can function as oncogenes or tumor suppressors.
  • Mechanisms underlying lncRNA involvement in MM pathogenesis are under investigation.
  • lncRNAs show promise as biomarkers for MM diagnosis and prognosis.

Conclusions:

  • lncRNAs are key players in MM initiation and progression.
  • Further research into lncRNA mechanisms is crucial for understanding MM.
  • lncRNAs represent promising targets for novel MM diagnostics and therapeutics.