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Related Concept Videos

Antimicrobial Effectiveness01:28

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The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
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Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
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Expression, Purification, and Antimicrobial Activity of S100A12
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Antimicrobial Metallopeptides.

Jessica L Alexander1, Zechariah Thompson1, J A Cowan1

  • 1Evans Laboratory of Chemistry , The Ohio State University , 100 West 18th Avenue , Columbus , Ohio 43210 , United States.

ACS Chemical Biology
|February 2, 2018
PubMed
Summary
This summary is machine-generated.

Antimicrobial peptides (AMPs) are key to innate immunity. This review explores how metals enhance AMP activity and their therapeutic potential for infections, including those linked to medical implants.

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Area of Science:

  • Biochemistry
  • Immunology
  • Microbiology

Background:

  • Antimicrobial peptides (AMPs) are crucial components of the innate immune system.
  • AMPs exhibit broad-spectrum activity against bacteria, fungi, protozoa, and viruses.
  • Their mechanisms of action include disrupting cellular processes and membranes.

Purpose of the Study:

  • To review the literature on metal-modulated antimicrobial peptides (metallopeptides).
  • To explore the influence of metals on AMP activity and mechanisms.
  • To discuss applications in drug delivery and treating implant-associated infections.

Main Methods:

  • Literature review of existing research on metallopeptides.
  • Analysis of studies detailing metal-peptide interactions.
  • Synthesis of findings on therapeutic applications.

Main Results:

  • Metals can modulate AMP activity through structural changes, sequestration, and redox chemistry.
  • Metallopeptides offer enhanced antimicrobial efficacy and novel mechanisms.
  • Potential applications in combating drug-resistant pathogens and implant infections.

Conclusions:

  • Metals significantly influence the efficacy and function of antimicrobial peptides.
  • Metallopeptides represent a promising area for developing new antimicrobial therapies.
  • Further research is warranted for clinical translation in drug delivery and infection treatment.