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Case report: Ribavirin and vitamin A in a severe case of measles
Amandine Bichon1, Camille Aubry, Lucas Benarous
1Aix Marseille Univ, CNRS 7278, IRD 198, INSERM 1095, AP-HM, URMITE, IHU Méditerranée-Infection, 19-21 Boulevard Jean Moulin, Marseille Cedex 5 Assistance Publique Hôpitaux de Marseille, CHU Timone, Service de réanimation médicale, Marseille, France.
Rationale:
Despite a vaccine being widely available, measles continues to occur frequently, with sometimes lethal consequences.
Patients Concerns:
The mortality rate reaches 35% and measles represents 44% of the 1.4 million deaths which are due to preventable diseases. Severe forms of measles are reported, mainly in young, unvaccinated adults, and in specific populations. The risk factors for severe measles include no or incomplete vaccination and vitamin A deficiency. Apart from secondary measles-related infections, severe measles is mainly represented by neurological, respiratory, and digestive symptoms.
Diagnoses:
Strengthening the hypothesis that there is a link between vitamin A deficiency and severe measles in this paper we report the case of a 25-year-old unvaccinated man hospitalized for severe and complicated measles.
Outcomes:
The evolution was good after administration of intramuscular vitamin A as well as intravenous ribavirin.
Lessons:
Measles remains a fatal and serious disease. The early use of ribavirin and vitamin A shows significant improvements regarding morbimortality and should be systematic in severe cases.
Insights
Measles remains a serious threat, especially in unvaccinated individuals. Early vitamin A and ribavirin treatment significantly improves outcomes for severe measles cases, reducing mortality.
Area of Science:
- Virology
- Immunology
- Public Health
Background:
- Measles vaccination is widely available, yet the disease persists with significant mortality.
- Severe measles disproportionately affects young, unvaccinated adults and specific populations.
- Key risk factors for severe measles include incomplete vaccination and vitamin A deficiency.
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