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Updated: Feb 15, 2026

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
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Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models

Published on: March 1, 2015

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Silent aspiration in infants with Prader-Willi syndrome identified by videofluoroscopic swallow study

Parisa Salehi1, Holly J Stafford, Robin P Glass

  • 1Division of Endocrine, Seattle Children's Hospital University of Washington School of Nursing, University of Washington Occupational Therapy Department, Seattle Children's Hospital Division of Rehabilitation Medicine, University of Washington Division of Developmental Medicine Division of Genetic Medicine Division of Pulmonary and Sleep Medicine Division of Gastroenterology and Hepatology, Seattle Children's Hospital, University of Washington, Seattle, WA, USA.

Medicine
|February 3, 2018
PubMed

Insights

Infants with Prader-Willi syndrome (PWS) frequently experience silent aspiration, indicating significant swallowing dysfunction. Early, multidisciplinary feeding and swallowing evaluations are crucial for managing PWS patients.

Area of Science:

  • Pediatric Gastroenterology
  • Neurology
  • Genetics

Background:

  • Feeding intolerance is common in Prader-Willi syndrome (PWS) infants.
  • Swallow physiology and dysfunction in PWS infants are not well understood.
  • Swallow dysfunction increases risks of respiratory compromise and choking in PWS.

Purpose of the Study:

  • To investigate swallow pathology in infants with Prader-Willi syndrome.
  • To determine if videofluoroscopic swallow studies (VFSS) can characterize swallow pathology and feeding safety.
  • To correlate VFSS findings with polysomnography (PSG) data.

Main Methods:

  • Retrospective review of 23 VFSS in 10 PWS infants (average age 9.7 months).
  • Logistic regression analyzed associations between gender, genetic subtype, and growth hormone (GH) use on aspiration.
  • PSG studies were reviewed for respiratory abnormalities.

Main Results:

  • High rates of swallowing dysfunction observed: 71% pharyngeal residue, 87% aspiration events.
  • All aspiration events were silent.
  • No significant differences in aspiration rates based on gender, genetic subtype, or GH use.

Conclusions:

  • Infants with PWS have a high incidence of aspiration, suggesting frequent swallow dysfunction.
  • Comprehensive, multidisciplinary feeding and swallowing evaluations are essential for PWS infants.
  • Recognizing risk factors and adopting a multidisciplinary approach optimize feeding safety.

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