Related Experiment Video

Updated: Feb 15, 2026

Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay
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Practical Considerations in Studying Metastatic Lung Colonization in Osteosarcoma Using the Pulmonary Metastasis Assay

Published on: March 12, 2018

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Endostar combined with chemotherapy in a pediatric osteosarcoma with pulmonary metastasis and malignant pleural

Sujing Jiang1, Guannan Wang, Ying Dong

  • 1Department of Medical Oncology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Medicine
|February 3, 2018
PubMed
Abstract

Insights

Endostar, a recombinant human endostatin, effectively treated a pediatric osteosarcoma case with metastasis. The patient achieved complete remission and remains progression-free, suggesting a potential new treatment strategy.

Area of Science:

  • Oncology
  • Molecular Biology

Background:

  • Angiogenesis is crucial for tumor growth and metastasis in cancers and sarcomas.
  • Endostar (recombinant human endostatin) is a novel therapeutic agent that inhibits tumor progression by suppressing VEGF and key signaling pathways like ERK, MAPK, and AKT.

Observation:

  • A pediatric patient diagnosed with osteosarcoma presented with pulmonary metastasis and malignant pleural effusion.
  • The patient's condition necessitated a tailored treatment approach due to their physical state.

Findings:

  • The patient received a combination of Endostar and chemotherapy, followed by Endostar monotherapy for 47 cycles.
  • This treatment regimen resulted in a pathologic complete remission.
  • The patient has maintained progression-free survival to date.

Implications:

  • This case highlights Endostar's potential as a viable treatment strategy for pediatric osteosarcoma with extensive metastasis.
  • The findings suggest Endostar could be a valuable option for managing complex cases involving pulmonary and pleural involvement.

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