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Ptosis induced by topical steroid eye drops: Two cases reports
Yanan Zhu1, Chaohui Sun, Xin Zhang
1Eye Center, 2nd Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang, China.
Medicine
|February 3, 2018
Summary
Topical steroid eye drops can cause ptosis, a rare complication. Long-term use may lead to levator muscle apoptosis and weakness, resulting in eyelid drooping.
Area of Science:
- Ophthalmology
- Cell Biology
Background:
- Ptosis is a rare complication associated with periocular steroid use.
- While local steroid injections are known to cause ptosis, this study examines cases from long-term topical steroid eye drop use.
Observation:
- Two patients developed ptosis in their right eye after prolonged use of topical steroid eye drops for uncontrolled Posner-Schlossman syndrome.
- Both cases were diagnosed with steroid-related ptosis.
Findings:
- Histopathological examination revealed levator muscle apoptosis and levator palpebrae superioris aponeurosis (LPSA) weakness in the affected eye.
- Surgical intervention in one patient resulted in symmetrical appearance during a 1-year follow-up.
Implications:
- Topical steroids may induce apoptosis in levator muscles and weaken the LPSA, leading to ptosis.
- This suggests a need for careful monitoring of eyelid function in patients using topical steroids long-term.
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