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Efficacy of Cellular Therapy for Diabetic Foot Ulcer: A Meta-Analysis of Randomized Controlled Clinical Trials

Ye Zhang1, Hong Deng1, Zhouping Tang1

  • 11 Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Cell Transplantation
|February 3, 2018
PubMed

Insights

Cellular therapy significantly accelerates diabetic foot ulcer healing and improves patient outcomes. This safe treatment enhances healing rates, reduces pain, and lowers amputation risk compared to standard care.

Area of Science:

  • Regenerative Medicine
  • Diabetology
  • Wound Healing Research

Background:

  • Diabetic foot ulcer (DFU) is a severe complication of diabetes mellitus, posing a significant global health challenge.
  • Existing treatments for DFU have limitations, highlighting the need for novel therapeutic approaches.
  • Cellular therapy has emerged as a promising strategy for DFU management, supported by preclinical and clinical evidence.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the efficacy and safety of cellular therapy in managing diabetic foot ulcers.
  • To synthesize data from randomized controlled trials (RCTs) to provide a comprehensive assessment of cellular therapy's impact on DFU healing.

Main Methods:

  • Systematic literature search of PubMed, MEDLINE, EMBASE, and Cochrane Library databases up to May 2017.
  • Inclusion of 6 randomized controlled trials involving 241 participants.
  • Meta-analysis to quantify the effects of cellular therapy on key DFU healing parameters.

Main Results:

  • Cellular therapy demonstrated significant improvements in healing metrics, including higher ankle-brachial index (MD = 0.17) and transcutaneous oxygen pressure (SMD = 1.43).
  • Higher ulcer healing rates (RR = 1.78), improved amputation-free survival (RR = 1.25), and reduced pain scores (SMD = -1.69) were observed.
  • The therapy was found to be safe, with no serious adverse events and a low incidence of minor short-term complications.

Conclusions:

  • Cellular therapy effectively accelerates the healing process of diabetic foot ulcers.
  • It offers superior outcomes compared to standard therapy for diabetic foot treatment.
  • The safety profile supports its consideration as a viable therapeutic option for DFU.
Keywords:
cell transplantationdiabetes mellitusdiabetic footmeta-analysis

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