Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Folic acid enhances lithium prophylaxis.

A Coppen, S Chaudhry, C Swade

    Journal of Affective Disorders
    |January 1, 1986
    PubMed
    Summary

    Folic acid supplements significantly reduced affective morbidity in patients on lithium therapy. Those with higher plasma folate levels experienced a 40% reduction, suggesting higher doses for long-term prophylaxis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    PERIPHERAL SEROTONERGIC AND ADRENERGIC RESPONSES IN DEPRESSION.

    Acta psychiatrica Scandinavica·2017
    Same author

    TRACE AMINE DEFICIT IN DEPRESSIVE ILLNESS: THE PHENYLALANINE CONNEXION.

    Acta psychiatrica Scandinavica·2017
    Same author

    Frequency of gonadal tumours in complete androgen insensitivity syndrome (CAIS): A retrospective case-series analysis.

    Journal of pediatric urology·2017
    Same author

    Safety in out-of-hours operating in trauma and orthopaedics at a district general hospital.

    Annals of the Royal College of Surgeons of England·2016
    Same author

    The pharmacogenetics of codeine pain relief in the postpartum period.

    The pharmacogenomics journal·2015
    Same author

    Science in brief: recent advances into understanding tendon function and injury risk.

    Equine veterinary journal·2015

    Area of Science:

    • Psychiatry
    • Nutritional Neuroscience

    Background:

    • Lithium therapy is a cornerstone for managing bipolar disorder.
    • Affective morbidity remains a challenge for patients undergoing long-term lithium treatment.
    • Folate metabolism plays a role in neurotransmitter synthesis and mood regulation.

    Purpose of the Study:

    • To investigate the efficacy of folic acid supplementation in reducing affective morbidity in patients on lithium therapy.
    • To determine the optimal plasma folate concentration for achieving mood stabilization.

    Main Methods:

    • A double-blind, placebo-controlled trial involving 75 patients on lithium therapy.
    • Daily administration of 200 micrograms of folic acid or a matched placebo.
    • Monitoring of plasma folate concentrations and assessment of affective morbidity.

    Main Results:

    • Patients with the highest plasma folate concentrations demonstrated a significant reduction in affective morbidity.
    • Achieving plasma folate levels of 13 ng/ml or higher correlated with a 40% decrease in affective morbidity.
    • Folic acid supplementation was well-tolerated in the study population.

    Conclusions:

    • Daily folic acid supplementation may be beneficial for reducing affective morbidity in patients on long-term lithium therapy.
    • A daily intake of 300-400 micrograms of folic acid is suggested to maintain optimal plasma folate levels for prophylaxis.
    • Further research is warranted to confirm these findings and establish precise dosage recommendations.

    Related Experiment Videos