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Updated: Feb 15, 2026

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An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
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A case of multiple myeloma initially presenting as hematemesis
1Department of Gastroenterology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Summary
Hematemesis, or vomiting blood, can be an initial symptom of multiple myeloma. Gastrointestinal amyloidosis should be considered in multiple myeloma patients presenting with this rare sign.
Area of Science:
- Gastroenterology
- Hematology
- Oncology
Background:
- Multiple myeloma is a plasma cell malignancy.
- Gastrointestinal bleeding is a known complication of multiple myeloma.
- Hematemesis as an initial presentation is rare.
Observation:
- A case of multiple myeloma presenting with hematemesis is reported.
- Gastroscopy revealed gastric ulceration.
- Colonoscopy identified ulcers in the ascending colon.
Findings:
- Tissue biopsy confirmed gastrointestinal amyloidosis.
- Bone marrow biopsy confirmed multiple myeloma.
- Hematemesis was the initial presenting symptom.
Implications:
- Hematemesis can be an early indicator of multiple myeloma.
- Gastrointestinal amyloidosis should be suspected in multiple myeloma patients with hematemesis.
- Early diagnosis and management are crucial for improved outcomes.
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