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Updated: Feb 15, 2026

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Association between fok1 polymorphism of vitamin D receptor gene with uterine leiomyoma in Turkish populations
Seda Güleç Yılmaz1, Tuğçe Gül1, Rukset Attar2
1Department of Molecular Medicine, Yeditepe University, Institute of Health Sciences, İstanbul, Turkey
Objective:
The aim of this research was to determine the association between the fok1 polymorphism and uterine leiomyomas.
Material And Methods:
For genotyping the fok1 polymorphism of the vitamin D receptor, real-time polymerase chain reaction was performed on blood samples of uterine leiomyoma (n=27) and control (n=33) groups. For statistical analyses, SPSS v.23 software (SPSS Inc., Chicago, IL, USA) was used.
Results:
A statistically significant difference was observed for the frequency of the CC genotype between the uterine leiomyoma and control groups, and the frequencies of the T allele in the uterine leiomyoma groups were significantly higher than in the control group.
Conclusion:
The presence of the fok1 CC genotype may be a risk-reducing factor and the T allele may be a potential risk factor for developing uterine leiomyoma.
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